Yashoda hospital Centre for Bone Marrow Transplant is part of Yashoda hospital that aims to provide patients with non-intrusive, compassionate care while advancing the understanding, treatment, cure, and prevention of blood-related diseases.
Yashoda's Haploidentical donor transplant unit is supported by a team of proficient experts who hold years of experience in performing Haploidentical Donor Transplantation. Our team has consistently treated a wide range of blood disorders and blood cancers. Our multidisciplinary team provides round-the-clock service and high-quality treatment to meet the individual needs of each patient in the best way possible.
There have been researches which have proved that less than 30% of the patient's find a stem cell match among family members. And in the case of people with mixed race, this number decreases to 5%. Approximately 70% of patients who do not have an HLA-identical sibling donor undergo haploidentical stem cell transplantation treatment to cure their blood-related disorders.
The term haploidentical donor indicates a half-matched donor, whose human leukocyte antigen (HLA) tissue type matches with that of the patient's. A patient undergoes haploidentical stem cell transplantation when he/she has no matched donor is available. Usually, a half donor is:
A haploidentical transplant is a form of allogeneic transplantation, which comprises the use of healthy, blood-forming cells from a half-matched donor to replace the unhealthy ones.
There are numerous severe health conditions related to blood disorders that require bone marrow transplant as a cure. Such illnesses include:
What Is The Procedure Of The Transplantation?
A haploidentical transplant is a newer form of transplant, which is a potentially curative therapy for a wide variety of malignant and non-malignant disorders related to blood and bone marrow. The transplantation procedure includes the following steps:
Step 1: Pretransplant Process: To ensure their general health and the status of the current medical condition, a patient has to take a series of Pre-transplant tests and procedures. This process of analysis may take several days.
The process includes:
Step 2: Conditioning Process: After the completion of the medical evaluation, a patient undergoes the conditioning process. This process involves the use of either chemotherapy or radiation therapy or a combination to:
Step 3: Haploidentical Transplant: For the cytotoxic treatment, the patient has to undergo the transplantation of the harvested where processed cells are put back into the patient's body, through a central venous catheter. These cells then move through the bloodstream into the bones' places, where they tend to create new bone marrow. The transplant provides a patient's body with a tendency to create new blood cells in a process, which is known as engraftment.
Step 4: Engraftment: The patient is kept under close monitoring for the sign of the growth of new stem cells along with supportive care.
Step 5: The Patient undergoes Post Engraftment monitoring and continuation of immunosuppression
What Are The Precautions One Must Take Before And After The Transplantation?
The precautions a patient must follow on a doctor's advice, before and after the transplantation process include:
Before the transplant:
After the transplant:
Are There Any Complications Involved?
Usually, a patient receives high-intensity doses of chemotherapy or radiation therapy before a transplant, resulting in complications such as:
Other complications due to transplant include:
The clinical research is still being conducted for haploidentical transplant, which is a relatively new approach to transplantation. However, it has shown same success rate as that of conventional transplants.
We are eager to help you at every step of your medical journey from hospital and back to your home.